Research

Research

We believe immunotherapy is the best path to a cure for brain tumor patients. Our research is driven by a deep understanding of the tumor microenvironment, with a special focus on the states of myeloid cells within tumors. We concentrate on understanding how these cells hinder the effectiveness of immunotherapies and explore strategies to transform their function to enhance the efficacy of these treatments.

Exploring the Myeloid Landscape in Gliomas

Our investigations focus on dissecting the complex roles of myeloid cells within brain tumors. These cells, which normally protect and repair tissue, can be co-opted by tumors to support their growth and evade the immune system. By mapping the origins, states, and regulatory mechanisms of immunosuppressive myeloid cells in patient tumors, we aim to unveil new therapeutic targets.

Video Presentation at the Myeloid Network on our approaches.

Innovative Methodologies

Our research is built on cutting-edge technologies:

Single cell genomics

Single cell genomics

Spatial Transcriptomics

Spatial Transcriptomics

Advanced Organoid Models

Advanced Organoid Models

We utilize these methods to create detailed profiles of tumor microenvironments, model the interactions between myeloid cells and tumor cells dynamically, and test new therapies. This platform enables us to accelerate both discovery and translation.

Translational Impact

Our lab is committed to translating these scientific insights into clinical applications. Through collaborations with clinicians and other research teams, we work tirelessly to bring our laboratory findings to the bedside. Our ultimate goal is to improve the survival and quality of life for brain tumor patients by integrating novel immunotherapeutic strategies with existing treatments.